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Wouter Meuleman

Investigator

Altius Institute

Biography

Wouter Meuleman’s research focuses on how the regulatory genome is organized, and what the functional implications of this organization are.

Although technological developments have made it possible to construct genome-wide maps of regulatory elements across hundreds of human cellular conditions, the scale and complexity precludes routine utility of such maps. Wouter develops computational and machine learning approaches to reduce their complexity, while maximally retaining relevant information.

Prior to joining Altius, Wouter did postdoctoral work at MIT and the Broad Institute. He obtained his PhD in Computational Biology from Delft University of Technology, the Netherlands.

Interests

  • Computational Biology
  • Regulatory Genomics
  • Epigenomics
  • Machine Learning
  • Data Visualization

Education / Experience

  • Postdoctoral Associate, 2012-2016

    Massachusetts Institute of Technology

  • PhD in Computational Biology, 2012

    Delft University of Technology, NL

  • MSc in Computer Science, 2005

    Leiden University, NL

Research

Annotated regulatory Index

Chromatin accessibility patterns across 700+ biosamples

Data saliency - epilogos

Information-theoretic analysis of chromatin state maps

Chromatin state maps

Epigenomic profiles of 100+ human cell types

Lamina Associated Domains

High-level chromosome folding and genome organization

Projects

Side projects typically unrelated to Computational Biology

Chasing Corona

Daily-updated analysis of confirmed COVID-19 coronavirus cases across the world

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