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Wouter Meuleman

Wouter Meuleman

Principal Investigator
Altius Institute

Affiliate Associate Professor
University of Washington

Biography

Wouter Meuleman’s research focuses on how the regulatory genome is organized, and what the functional implications of this organization are. His long term research goal is to make “augmented genomics” a reality: a new field in which the work of genome scientists is supplemented – not replaced! – by large-scale visualization and data-driven machine intelligence.

Although technological developments have made it possible to construct genome-wide maps of regulatory elements across hundreds of human cellular conditions, the scale and complexity precludes routine utility of such maps. Wouter develops computational and machine learning approaches to reduce their complexity, while maximally retaining relevant information.

Prior to joining Altius, Wouter did postdoctoral work at MIT and the Broad Institute. He obtained his PhD in Computational Biology from Delft University of Technology and the Netherlands Cancer Institute, the Netherlands.

In 2020, Wouter was the recipient of an NHGRI Genomic Innovator Award, which provides flexible funding for a five year period.

Interests
  • Computational Biology
  • Regulatory Genomics
  • Epigenomics
  • Machine Learning
  • Data Visualization
Education
  • PhD in Computational Biology, 2012

    Delft University of Technology, NL

  • MSc in Computer Science, 2005

    Leiden University, NL

Research

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Synthetic DNA sequences
Data-driven design of context-specific regulatory elements
Annotated regulatory Index
Chromatin accessibility patterns across 700+ biosamples
Data saliency - epilogos
Information-theoretic analysis of chromatin state maps
Chromatin state maps
Epigenomic profiles of 100+ human cell types
Lamina Associated Domains
High-level chromosome folding and genome organization

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